The course introduces key issues related to promoting sustainable desalination operations in today’s desalination industry. The course analyzes developments in the desalination industry using the three elements of sustainability: cost, society, and the environment. This course aims to help the students approach the desalination industry with sustainability in mind. As the desalination industry booms and new desalination-related systems, designs, processes, and products are introduced every year, these new developments could best be judged by their sustainability. In this context, the course covers topics such as environmental impacts of desalination processes, understanding water production via desalination within the water-energy-cost nexus, designing safe and sustainable intake and outfall systems for desalination plants, assessing the economic feasibility of new desalination processes, evaluation of renewable?energy?powered desalination processes, evaluation and applications of novel desalination systems, such as membrane distillation and forward osmosis, recent technological improvements for enhanced desalination processes, and fouling issues in RO membranes. To better convey the course concepts, case studies will be presented.